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Company: Eli Lilly
Primary Section: Genitourinary System - Erectile dysfunction agents
Pregnancy Category: B1 - Drugs which have been taken by only a limited number of pregnant women and women of childbearing age without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have not shown evidence of an increased occurrence of fetal damage. Permitted in sport
Cialis (Tablets) Tadalafil; lactose; light yellow (5, 10 mg), yellow (20 mg), f-c, marked C and strength; gluten free. Drug Class: Rx Pack: 10 mg [4] Pack: 20 mg [4] Pack: 20 mg [8] Pack: 5 mg [28] Dose: May be taken with or without food. On demand dosing: admin up to once daily ½-36 hours before sexual activity. Adults: max. 20 mg/dose; may decrease to 10 mg based on response and tolerability. Renal impairment. Mild to moderate: initially 10 mg/dose; may increase to 20 mg/dose. Severe: max. 10 mg/dose. Hepatic impairment: 10 mg/dose. Once a day dosing: admin once daily. Adults: 5 mg/day; may decrease to 2.5 mg/day; max. 5 mg/day. Severe renal impairment: not recommended. Discontinuation: monitor CV status incl BP.
Uses: PDE5 inhibitor. Treatment of erectile dysfunction in adult males. Contraindications: Loss of vision in one eye due to nonarteritic anterior ischaemic optic neuropathy (NAION); concomitant or intermittent use of nitrates, nitrites, nitric oxide donors (e.g. GTN, isosorbide salts, Na nitroprusside, amyl nitrite, nicorandil) incl some recreational drugs. Precautions: Renal (ClCr < 50 ml/min), hepatic insufficiency; where sexual activity inadvisable; anatomical penis deformation, e.g. angulation, cavernosal fibrosis, Peyronie's disease; priapism predisposition incl sickle cell anaemia, multiple myeloma, leukaemia; CV disease (or risk factors) incl angina, uncontrolled arrhythmia or hypertension, BP 50 years; children < 18 years. Adverse reactions: Common: headache, GI upset (very common); flushing; nasal congestion; back pain; muscle ache; dizziness; infection; pharyngitis. Uncommon: epistaxis; sudden hearing loss; blurred vision; conjunctival hyperaemia; eyelid swelling; eye, chest pain; palpitation; tachycardia; hyperhidrosis; hypo, hypertension; hypersensitivity. Rare: altered colour vision; visual field defect; facial oedema; stroke; syncope; MI. Unknown frequency: abnormal ECG; NAION; priapism; spontaneous erection; severe skin reactions; retinal vein occlusion; others, see full PI. Interactions: See Contraindications; other erectile dysfunction treatments; CYP3A4 inhibitors (e.g. ketoconazole, ritonavir), inducers (e.g. rifampicin); nonselective a-blockers, e.g. doxazosin; antihypertensives; warfarin; antacids; ethinyloestradiol; HIV protease inhibitors; high alcohol intake; oral terbutaline (possible). Patient Information: May affect ability to drive or operate machinery; take care until effects are known. Seek immediate medical attention if erection persists > 4 hours. Discontinue all PDE5 inhibitors and contact doctor immediately if sudden vision or hearing loss occurs. Refrain from further sexual activity and report incidence to doctor if CV symptoms are experienced.
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