Pharmacy on Web

23 February 2010

There is a potential health risk from long-term excessive use of GSK's(Glaxosmithkline) zinc- containing denture adhesive cream Polident Extra Hold Denture Adhesive Cream. Patient safety is the reason GSK has taken these measure and have voluntarily stopped the manufacture,distribution and advertising of this product. There are a variety of sources of zinc and it is an essential part of a healthy diet. However, in
2009 we received an increased number of adverse event reports. Together with the published literature", these suggest that excessive use of these products, typically for several years, may lead to the development of excessive levels of zinc in the body (associated with copper deficiency).

The reports describe the development of myeloneuropathy and blood dyscrasias. Neurological symptoms may include sensory disturbance, limb weakness and difficulty walking. These reports are very rare, given that several million people are users of the products. It is important to note that zinc is not absorbed through the mouth, remaining bound to the adhesive and is only absorbed when swallowed. A small amount of adhesive is swallowed during normal use. This is not considered to be harmful. Patients who have used Polident Extra Hold Denture Adhesive Cream in accordance with the instructions may continue to do so safely. While the majority of patients do use these products safely, some patients apply more adhesive than directed and use it more than once per day, usually due to ill-fitting dentures. Patients can call the GSK hotline if they experience any neurological symptoms associated with long term excessive denture adhesive use, call 0800 540144 and tell them that you would like to report an Adverse Event